罗米|中国首个抗新冠「特效药」为何能顶住奥密克戎的“突袭”？丨奇点深度( 三 ) 深度|特效药|组合|研究|密克

总的来说，从现有的研究来看，安巴韦单抗和罗米司韦单抗结合于RBD的两个完全不同、且互不干扰的位点，这让它们实现了真正的功能互补。另外，患者治疗后的超高血药浓度以及更高的肺部抗体浓度，也对安巴韦单抗/罗米司韦单抗对目前已知的所有变异株保持中和活性助力不小。
据了解，清华大学张林琦团队关于安巴韦单抗/罗米司韦单抗中和奥密克戎的研究即将发表，期待张教授给我们带来更全面的解答。
参考文献：
[2].https://www.krisp.org.za/manus/25Nov2021_B.1.1.529_Media.pdf
[3].Cao Y R, Wang J, Jian F, et al. B. 1.1. 529 escapes the majority of SARS-CoV-2 neutralizing antibodies of diverse epitopes[J]. BioRxiv, 2021.
[4].https://mp.weixin.qq.com/s/48JorUncaQ_isz07rBpVPw
[5].Liu L, Iketani S, Guo Y, et al. Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2[J]. nature, 2021.
[6].Baum A, Fulton B O, Wloga E, et al. Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies[J]. Science, 2020, 369(6506): 1014-1018.
[7].Piccoli L, Park Y J, Tortorici M A, et al. Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology[J]. Cell, 2020, 183(4): 1024-1042. e21.
[8].Corti D, Purcell L A, Snell G, et al. Tackling COVID-19 with neutralizing monoclonal antibodies[J]. Cell, 2021.
[9].Pinto D, Park Y J, Beltramello M, et al. Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody[J]. Nature, 2020, 583(7815): 290-295.
[10].Ge J, Wang R, Ju B, et al. Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry. Nat Commun. 2021;12(1):250. Published 2021 Jan 11.
[11]. Baum A, Fulton B O, Wloga E, et al. Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies[J]. Science, 2020, 369(6506): 1014-1018.
[12].Lempp FA, Soriaga LB, Montiel-Ruiz M, et al. Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies. Nature. 2021;598(7880):342-347.
[13].https://opendata.ncats.nih.gov/variant/activity
[14].Zhang Y, Hao X, Ma J, et al. Phase 1 safety and pharmacokinetics studies of BRII-196 and BRII-198, SARS-CoV-2 spike-targeting monoclonal antibodies[J]. medRxiv, 2021.
[16].Shah DK, Betts AM. Antibody biodistribution coefficients: inferring tissue concentrations of monoclonal antibodies based on the plasma concentrations in several preclinical species and human. MAbs. 2013;5(2):297-305. doi:10.4161/mabs.23684
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