文章图片
图6.氟西汀研发过程中两位重要的科学家BryanB.Molloy与DavidT.Wong丨图片来源:左https://www.invent.org/inductees/bryan-b-molloy;右:blogs.oregonstate.edu/)
科学的发展是一个不断积累的过程 。 神经科学的先驱们提供了生理学基础、开创性的设计思路 , 研究团队又通过深入的思考和不懈的努力来验证思路 , 遭受怀疑、嘲笑也不放弃 , 才最终取得了突破性的成果 。 就像DavidT.Wong在三十年以后回顾氟西汀的研发之路时说的那样:
Itisessentialthatideasaresteadfastlychampionedbypassionatebelieverstoachievethefinalgoal.
参考资料
[1]https://apps.who.int/iris/bitstream/handle/10665/93142/EML_18_eng.pdf;jsessionid=9633BBC4D3838AC972A59899C442C306?sequence=1
[2]Loomer,H.P.,Saunders,J.C.,&Kline,N.S.(1957).Aclinicalandpharmacodynamicevaluationofiproniazidasapsychicenergizer.PsychiatricResearchReports,8,129–141.
[3]FeighnerJ.P.(1999).Mechanismofactionofantidepressantmedications.TheJournalofclinicalpsychiatry,60Suppl4,4–13.
[4]Shaw,D.M.,Camps,F.E.,&Eccleston,E.G.(1967).5-Hydroxytryptamineinthehind-brainofdepressivesuicides.TheBritishjournalofpsychiatry:thejournalofmentalscience,113(505),1407–1411.
[5]BourneHR,BunneyWEJr,ColburnRW,etal.Noradrenaline,5-hydroxytryptamine,and5-hydroxyindoleaceticacidinhindbrainsofsuicidalpatients.Lancet.1968;2(7572):805-808.
[6]BaileyOT.TheStructureandFunctionofNervousTissue,vol3,BiochemistryandDisease.JAMA.1970;212(9):1528–1529.doi:10.1001/jama.1970.03170220082030
[7]WongDT,PerryKW,BymasterFP.Casehistory:thediscoveryoffluoxetinehydrochloride(Prozac).NatRevDrugDiscov.2005;4(9):764-774.doi:10.1038/nrd1821
[8]Molloy,B.B.,Wong,D.T.&Fuller,R.W.Thediscoveryoffluoxetine.PharmaceuticalNews1,6–10(1994).
[9]Wong,D.T.,Horng,J.S.,&Bymaster,F.P.(1975).dl-N-methyl-3-(o-methoxyphenoxy)-3-phenylpropylaminehydrochloride,Lilly94939,apotentinhibitorforuptakeofnorepinephrineintoratbrainsynaptosomesandheart.Lifesciences,17(5),755–760.https://doi.org/10.1016/0024-3205(75)90531-7
[10]WongDT,BymasterFP.Effectofnisoxetineonuptakeofcatecholaminesinsynaptosomesisolatedfromdiscreteregionsofratbrain.BiochemPharmacol.1976;25(17):1979-1983.doi:10.1016/0006-2952(76)90053-8
[11]WongDT,BymasterFP,HorngJS,MolloyBB.Anewselectiveinhibitorforuptakeofserotoninintosynaptosomesofratbrain:3-(p-trifluoromethylphenoxy).N-methyl-3-phenylpropylamine.JPharmacolExpTher1975;193(3):804-11
[12]WongDT,BymasterFP,ReidLR,ThrelkeldPG.Fluoxetineandtwootherserotoninuptakeinhibitorswithoutaffinityforneuronalreceptors.BiochemPharmacol.1983;32(7):1287-1293.doi:10.1016/0006-2952(83)90284-8
[13]BengtssonBO,WiholmBE,MyrhedM,W?linderJ.AdverseexperiencesduringtreatmentwithzimeldineonspeciallicenceinSweden.IntClinPsychopharmacol.1994;9(1):55-61.doi:10.1097/00004850-199400910-00009
【为了发明治抑郁症的良药,研究者没少抑郁】[14]https://www.psychologytoday.com/us/blog/freud-fluoxetine/202003/the-story-prozac-landmark-drug-in-psychiatry
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