第二个应对方案是 结合特定位点的中和抗体 。 虽然大部分中和抗体的活性都有所下降[23] , 但是已经有研究表明 ,结合S蛋白RBD位点IV的中和抗体(Sotrovimab和罗米司韦单抗)的活性 , 几乎不受Omicron变异株突变位点的影响[32] 。 这也是安巴韦单抗/罗米司韦单抗组合对Omicron变异株保持中和活性的原因之一 。
第三个应对武器是 小分子药物 。 已有多个实验室的研究表明 , 已经获得FDA批准获得紧急使用授权的三种小分子药物对所有当前的VOC活性保持不变[33,34] 。
有了这“三板斧” , 人类与新冠病毒之间的战争 , 也并非全无胜算 。
总的来说 , 随着科学家对新冠病毒和新冠肺炎认知的加深 , 我们逐渐能摸清楚新冠病毒的弱点 , 最终大概率能找到克敌制胜的突破口 。 或许很快人类就可以与新冠病毒“和平共处” 。
延伸阅读
参考文献:
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[4].Zaki A M, Van Boheemen S, Bestebroer T M, et al. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia[J]. New England Journal of Medicine, 2012, 367(19): 1814-1820.
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[13]. Weinreich D M, Sivapalasingam S, Norton T, et al. REGEN-COV antibody combination and outcomes in outpatients with Covid-19[J]. New England Journal of Medicine, 2021.
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