cpsp|【罂粟摘要】肺癌术后长期慢性疼痛的发生率情况：一项为期十年的单中心?回顾性研究

肺癌术后长期慢性疼痛的发生率情况：一项为期十年的单中心回顾性研究
贵州医科大学麻醉与心脏电生理课题组
翻译：安丽编辑：潘志军审校：曹莹
1 背景
目前尚无关于胸部术后长期慢性疼痛(CPSP)发生率的报道。
2 方法
我们回顾分析了2007年至2016年间4218例因肺癌接受胸部手术患者的电子病历。我们在36个月内每隔3个月评估一次胸部手术后CPSP的发生情况。采用Cox比例风险回归分析探讨胸部手术后CPSP的预测因素。
3 结果
共有3200名患者被纳入分析。其中459例（14.3%）和558例（17.4%）患者在术后3个月和36个月内被诊断为CPSP。随着时间的推移，CPSP的发生率降低。此外，99例(3.1%)患者在术后至少6个月被新诊断为CPSP。女性患者(风险比1.20, 95%可信区间1.00 -1.43;p=0.04)，手术时间较长的患者（风险比1.11，95%可信区间1.03-1.20；p<0.01），术后第一次门诊就诊时数值评定量表评分为11分较高的患者（风险比 1.29，95% 可信区间 1.24-1.34；p<0.001），术后化疗的患者（风险比 1.55,95% 可信区间1.26-1.90；p<0.001），术后放射治疗的患者（风险比1.35,95% 可信区间1.05-1.74；p=0.02），上述均为术后36个月CPSP的显著预测因子。
【 cpsp|【罂粟摘要】肺癌术后长期慢性疼痛的发生率情况：一项为期十年的单中心?回顾性研究】

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4 结论
我们的研究显示胸外科术后CPSP的发生率以及延迟发作或复发有降低的趋势，能更好地了解胸部术后CPSP的进展，可为其预测和治疗提供重要信息。
原始文献来源 ?
Susie Yoon, Won-Pyo Hong, Hyundeok Joo, Hansol Kim, Samina Park,Jae-Hyon Bahk,Ho-Jin Lee.Long-term incidence of chronic postsurgical pain after thoracic surgery for lung cancer: a 10-year single-center retrospective study.Reg Anesth Pain Med 2020 05;45(5).DOI：10.1136/rapm-2020-101292.
英文原文
Long-term incidence of chronic postsurgical pain after thoracic surgery for lung cancer: a 10-year single-center retrospective study
Abstract
Background:The long-term incidence of chronic postsurgical pain (CPSP) after thoracic surgery has not yet been reported.
Methods:We retrospectively reviewed the electronic medical records of 4218 consecutive patients who underwent thoracic surgery for lung cancer between 2007 and 2016. We evaluated the long-term incidence of CPSP after thoracic surgery at intervals of 3 months for 36 months. A Cox proportional hazard regression analysis was performed to investigate the predictors of CPSP after thoracic surgery.
Result:A total of 3200 patients were included in the analysis. Of these, 459 (14.3%) and 558 (17.4%) patients were diagnosed with CPSP within 3 and 36 months after surgery, respectively. Furthermore, the incidence of CPSP decreased over time. Additionally, 99 (3.1%) patients were newly diagnosed with CPSP at least 6 months after surgery. Female sex (HR 1.20, 95% CI 1.00 to 1.43; p=0.04), longer duration of surgery (HR 1.11, 95% CI 1.03 to 1.20; p<0.01), higher 11-point Numeric Rating Scale score at first outpatient visit after surgery (HR 1.29, 95% CI 1.24 to 1.34; p<0.001), postoperative chemotherapy (HR 1.55, 95% CI 1.26 to 1.90; p<0.001), and postoperative radiation therapy (HR 1.35, 95% CI 1.05 to 1.74; p=0.02) were significant predictors of CPSP for 36 months after surgery.